Boosting the Immune System to Treat Diabetic Retinopathy

Targeting RORγ to Boost Regulatory T cells and Ameliorate Diabetic Retinopathy in Mice

D Deliyanti, V Suphapimol, P Ang, A Jayasimhan, JL Wilkinson-Berka

2026-02-01

Diabetic retinopathy, a leading cause of blindness, features damage to the retinal vasculature, where T-cell–mediated inflammation..

Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3 Tregs and CD8 T cells

D Deliyanti, V Suphapimol, A Joglekar, A Jayasimhan, JL Wilkinson-Berka

2025-07-01

Aims/hypothesis: Diabetic retinopathy features damage to the retinal microvasculature that causes vessels to leak and proliferate ..